The hosts examine how pharmaceutical companies use TikTok influencers to market antidepressants and weight-loss drugs to young people. They describe "hot girl Prozac" merch and the normalization of "zappies" (brain shocks) from Zoloft withdrawal. Oprah Winfrey is again criticized for her ties to Weight Watchers and for promoting the idea that obesity is a "brain disease" rather than a result of sugar addiction.